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KMID : 0361020020450121179
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Korean Journal of Otolaryngology - Head and Neck Surgery
2002 Volume.45 No. 12 p.1179 ~ p.1183
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Immunohistochemical Study on the Expression of Laminin-5 in the Oral Cavity and Oropharyngeal Squamous Cell Carcinoma
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이형석/Hyung Seok Lee
태경/박혜경/한장희/조석현/김경래/Kyung Tae/Hye Kyung Park/Jang Hee Han/Seok Hyun Cho/Kyung Rae Kim
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Abstract
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Background and Objectives: Laminins are extracellular matrix proteins localized mainly in basement membranes. Currently there are at least ten different laminin chains and 11 heterotrimetric laminin variants. Laminin-5 is a heterotrimeric
basement membrane molecule (α3, β3, γ2). It serves as an important adhesion protein for epithelial cells and it also plays an important role in cell migration during tumor invasion and tissue remodeling. This
study
was designed to investigate the relationship between laminin-5 expression and clinicopathologic variables in oral cavity and oropharynx squamous cell carcinomas using immunohistochemistry. Materials and Method: The expression of the
laminin-5
around tumor cell was determined in 32 oral cavity and oropharyngeal carcinomas by immunohistochemical staining with antibody against laminin-5 γ2 chain. Results: Statistical analysis showed that the frequency of laminin-5 γ 2 chain
expression
was correlated with the lymph node metastasis (p<0.05). The poor differentiation of tumor cells, the large tumor size, advanced overall stage and the deep tumor invasion showed high expression of laminin-5, although it was not significant
statistically.
Conclusion: These results suggest that overexpression of laminin-5 in oral cavity and oropharyngeal squamous cell carcinoma might be a biomarker that can predict cervical lymph node metastasis.
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KEYWORD
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